Getting to Vatican
It's easy to get to the Vatican by taxi, bus or by foot from Rome—the closest neighborhood on the other side of the Tiber being Navona. Take the Metro line A to Cipro for the Museums, or Ottaviano for St. Peter's, or the tram to Piazza del Risorgimento .
From Central Rome, the #64 bus goes right to the southern end of the Vatican, but it is filled with pickpockets, guard your valuables! :) !
With a little more than 100 acres (less than half a square kilometer) within its walls, the Vatican is easily traveled by foot; however, most of this area is inaccessible to tourists. The most popular areas open to tourists are the Basilica of St. Peter and the Vatican Museums.
If you're heading up Monte Mario, wear comfortable shoes—it's quite a climb!